She is also just as into terrorizing the other kids as her other sisters, yet appears to be a little more tricky and intricate at times, as some scenes suggest. She seems to be the trickiest of the girls at times. A real rock chick, grungy, sweet but incredibly sour Marie is hysterically in love with Edd. Marie, the most aggressive and disruptive Kanker is the sister with the blue hair, black shirt and combat pants. She is the self-appointed leader perhaps, and possibly the oldest. Also, she is reluctant to let people touch her hair. In the episode "Look into My Eds" it's revealed that she, with the rest of the Kankers, are resistant to hypnosis. Dangerously in love with Eddy, she also treasures the Ship in a Bottle dearly. The most domineering and commanding sister, Lee is the girl with the red hair that covers her eyes and trademark spotted shirt. The Eds constantly are running away from their self-proclaimed "girlfriends." The Kankers are very possessive of the Eds and care deeply for them, and in one episode, they used the Abandoned House to trick the Eds into "marrying" them, a marriage that the Eds did not agree to. However, soon after the boys developed a strong dislike of the Kankers, as did the rest of the Cul-De-Sac kids. The Kanker Sisters then clothed the Eds in their three fathers' bathrobes while they hang their clothes out to dry and served them "Kanker Burgers". The girls made their debut in the episode "Nagged to Ed" where they moved to the Cul-De-Sac and found the Eds in the woods during Double D's monthly insect expedition, when the boys were cornered by the Kankers in a swampy pond and the sisters brought them back to their trailer home. This seems to suggest that they are actually half-sisters, sharing a mother but each having a different father, which would explain the lack of physical resemblance between them. While they are definitively sisters and all live together, they appear to have three different fathers but only one mother. The origins of the Kankers are convoluted. These sharply constrast with advertisements for car parts, a perfume of their own design called "Krankshaft No.5," and a penchant for wrestling each other. The lives of the Kanker sisters apparently revolves around activities such as painting their toenails, stylizing their hair, and reading such literature as "Hub Cap Digest." Their trailer holds a large amount of nautical-themed items, such as Fish Bowl 2, a stuffed swordfish, an anchor, a diver's helmet, and a ship in a bottle, which is a prized possession of their's. However, when the Eds began to push their luck, the Kankers felt rejected and felt the compulsion to torment the Eds ever since. At first, the Kankers appeared to be kind-hearted, performing domestic services for the Eds such as cooking and washing clothes. Sometimes, they become manic possessive towards the Eds other times, they will simply yearn for romance and sometimes they simply abuse them.
The Kankers are essentially the equals of the Eds, who cycle through feelings of love and hate for them. The Kankers' idea of a vacation is a trip with their trailer to Eddy's House. For obvious reasons, the majority of the cul-de-sac seem to fear them.
While all three sisters apparently love all of the Eds, May prefers Ed, Marie prefers Edd, and Lee prefers Eddy, though Eddy seems to be the most tormented of the three. Many episodes conclude with the Eds encountering unwanted kisses from them or by harassing them. Although they are obsessed or even in love with the Eds, they still torment, tease, and torture them, although usually in an exaggerated "lovey dovey" way. Despite having only one mother, they also have three fathers. They live in the "Park n' Flush" Trailer Park. They were introduced in "Nagged to Ed", which was the second part of the first episode. The Kanker Sisters are a family of sisters, who each have a crush on the Eds, and are the bullies of Peach Creek, attacking everyone in the Cul-de-Sac. Nazz,Kevin,Jonny 2x4,Sarah,Jimmy,Plank,The Eds (they think the eds are there boyfriends but the eds hate em)Urban Rangers Main antagonists - Tomboys - Obsessed with the Eds Unknown (mentioned in Nagged to Ed that they are not from Peach Creek) The Sisters of the Friend Stealer (Lee and Marie)